Cardiomyopathy is a group of diseases that affect the. Early on there may be few or no symptoms.
Get this from a library! Pathophysiology of heart disease: a collaborative project of medical students and faculty. Leonard S Lilly; Harvard Medical School.; - This study of the pathophysiology of heart disease is designed for second year medical students.
Some people may have, feel, or have due to. Dynamic link download cs6 windows. An may occur as well as. Those affected are at an increased risk of. Types of cardiomyopathy include, and (broken heart syndrome). In hypertrophic cardiomyopathy the heart muscle enlarges and thickens. In dilated cardiomyopathy the enlarge and weaken. In restrictive cardiomyopathy the ventricle stiffens.
The cause is frequently unknown. Hypertrophic cardiomyopathy is often, and dilated cardiomyopathy in a third of cases is from a person's parents. Dilated cardiomyopathy may also result from, use, and. Restrictive cardiomyopathy may be caused by, and some. Broken heart syndrome is caused by extreme emotional or physical stress. Treatment depends on the type of cardiomyopathy and the degree of symptoms. Treatments may include lifestyle changes, medications, or surgery.
In 2015 cardiomyopathy and affected 2.5 million people. Hypertrophic cardiomyopathy affects about 1 in 500 people while dilated cardiomyopathy affects 1 in 2,500. They resulted in 354,000 deaths up from 294,000 in 1990. Arrhythmogenic right ventricular dysplasia is more common in young people. The arrhythmia, seen on an ECG Symptoms of cardiomyopathies may include fatigue, swelling of the lower extremities and. Further indications of the condtion may include:.
Fainting. Diziness Causes Cardiomyopathies are either confined to the heart or are part of a generalized systemic disorder, both often leading to cardiovascular death or progressive heart failure-related disability. Other diseases that cause heart muscle dysfunction are excluded, such as, or abnormalities of the. Often, the underlying cause remains unknown, but in many cases the cause may identifiable. Alcoholism, for example, has been identified as a cause of dilated cardiomyopathy, as has drug toxicity, and certain infections (including ).
On the other hand, molecular biology and genetics have given rise to the recognition of various genetic causes. For example, mutations in the cardiac desmosomal genes as well as in the DES gene may cause arrhythmogenic right ventricular cardiomyopathy (ARVC). A more clinical categorization of cardiomyopathy as 'hypertrophied', 'dilated', or 'restrictive', has become difficult to maintain because some of the conditions could fulfill more than one of those three categories at any particular stage of their development. The current definition divides cardiomyopathies into primary, which affect the heart alone, and secondary, which are the result of illness affecting other parts of the body. These categories are further broken down into subgroups which incorporate new genetic and molecular biology knowledge. Mechanism Symptoms may include shortness of breath after physical exertion, fatigue, and swelling of the feet, legs, or abdomen. Additionally, and chest pain may be present.
The pathophysiology of cardiomyopathies is better understood at the cellular level with advances in molecular techniques. Mutant proteins can disturb cardiac function in the contractile apparatus (or mechanosensitive complexes). Cardiomyocyte alterations and their persistent responses at the cellular level cause changes that are correlated with sudden cardiac death and other cardiac problems. Diagnosis.
Pathophysiology Of Heart Disease Leonard Lilly Pdf Editor 2017
Hypertrophic cardiomyopathy HE stain Cardiomyopathies can be classified using different criteria:. Primary/intrinsic cardiomyopathies. Genetic.
(ARVC). LV non-compaction. Ion Channelopathies. (DCM). (RCM). Acquired.
Secondary/extrinsic cardiomyopathies. Metabolic/storage.
Fabry's disease. Endomyocardial. Endocrine. Cardiofacial. Neuromuscular. Other.
Obesity-associated cardiomyopathy Treatment Treatment may include suggestion of lifestyle changes to better manage the condition. Treatment depends on the type of cardiomyopathy and condition of disease, but may include medication (conservative treatment) or iatrogenic/implanted for slow heart rates, for those prone to fatal heart rhythms, (VADs) for severe heart failure, or for recurring dysrhythmias that cannot be eliminated by medication or mechanical cardioversion. The goal of treatment is often symptom relief, and some patients may eventually require a. References.